Incidence of Incomplete Postoperative Neuromuscular Recovery From Anesthesia (P07535)(Completed) (INSPIRE)

Merck Sharp & Dohme (MSD)

Status: Completed

Conditions: Neuromuscular Blockade

Treatments: Other: Neuromuscular Blocking Agent (NMBA)

Study type: Observational

Funder types: Industry

Identifiers

NCT01181349

P07535

Details and patient eligibility

About

This is a multicenter, observational study in adult participants undergoing different types of elective surgical procedures requiring general anesthesia. During the first study period, there will be a cross-sectional evaluation of neuromuscular blockade level upon participant arrival at Post Anesthesia Care Units (PACUs). During the second study period, hospital discharge data from the participants will be collected. The purpose of this study is to determine the incidence of incomplete postoperative neuromuscular recovery from anesthesia at PACUs in Portuguese hospitals. This is a cross-sectional and retrospective study.

Enrollment: 350 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years of age or older
• Informed consent signed
• Admission for elective surgery
• Administration of nondepolarizing NMBAs during surgery

Exclusion criteria

• Admission for emergency surgery
• Reoperation on the same hospital admission

Trial design

350 participants in 2 patient groups

P07535 study participants with a TOF ratio <0.9

Description:

Participants enrolled in the P07535 study who are included in the primary outcome measurement, which is defined as the incidence of postoperative residual neuromuscular blockade, who had a TOF ratio \<0.9 at PACU arrival.

Treatment:

Other: Neuromuscular Blocking Agent (NMBA)

Other: Neuromuscular Blocking Agent (NMBA)

P07535 study participants with a TOF ratio ≥0.9

Description:

Participants enrolled in the P07535 study who are included in the primary outcome measurement, which is defined as the incidence of postoperative residual neuromuscular blockade, who had a TOF ratio ≥0.9 at PACU arrival.

Treatment:

Other: Neuromuscular Blocking Agent (NMBA)

Other: Neuromuscular Blocking Agent (NMBA)