Incidence of Invasive Pulmonary Aspergillosis in Ventilator-associated Pneumonia (ASPIC)

University Hospital, Lille

Status: Completed

Conditions: Ventilator Associated Pneumonia; Pulmonary Aspergillosis Invasive

Treatments: Other: Biological examinations performed on blood and BAL

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT05671328

2022_0061

2022-A00496-37 (Other Identifier)

Details and patient eligibility

About

Mechanically ventilated patients are at risk of developing ventilator-associated pneumonia (VAP). Invasive pulmonary aspergillosis (IPA), the diagnosis of which motivates the implementation of specific treatments, is one of the causes of VAP. The hypothesis of the study is that the incidence of IPA is 12.4%. For each patient presenting with a suspicion of VAP and requiring a bronchoalveolar lavage (BAL), the diagnosis of API will be evaluated by biological examinations performed on blood and BAL. Medical and surgical history as well as clinical and biological data will be collected for 28 days or until discharge from the ICU.

Enrollment: 263 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient (age ≥ 18 years),

• On invasive ventilation for more than 48 hours,

• Suspected VAP, defined by the appearance or worsening of a radiological pulmonary infiltrate, associated with 2 of the following clinical criteria:

  • Fever ≥ 38° C or hypothermia ≤ 36.5° C
  • Leukocytes > 12x109 or < 4x109/L
  • Purulent tracheal secretions

Exclusion criteria

• Neutropenic patients (neutrophils < 0.5G/L),
• Previous diagnosis of IPA,
• Minor patients.

Trial design

263 participants in 1 patient group

Patients with suspected ventilator-associated pneumonia

Treatment:

Other: Biological examinations performed on blood and BAL