Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo

Momentum Data

Status: Completed

Conditions: Squamous Cell Carcinoma; Vitiligo; Melanoma (Skin); Actinic Keratoses; Nonmelanoma Skin Cancer; Basal Cell Carcinoma

Treatments: Other: Exposure of skin cancer of interest

Study type: Observational

Funder types: Industry

Identifiers

NCT04969419

P045

Details and patient eligibility

About

This study examines melanoma and nonmelanoma skin cancer in people diagnosed with vitiligo compared to matched controls.

Full description

For the primary analysis, this study examines the risk of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma in people diagnosed with vitiligo. It also examines actinic keratoses. In secondary analysis, this study examines the prevalence of skin cancer in people diagnosed with vitiligo compared to matched controls.

This study also examines whether the susceptibility to melanoma and nonmelanoma skin cancer may vary between different patient subgroups, e.g. ethnicity, those who undergo phototherapy or treatment with the new targeted biologic immunosuppressive therapies.

Enrollment: 75,771 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All eligible adult patients (aged ≥ 18) registered with General Practioner (GP) practices contributing data to OPCRD between January 1, 2010 and December 31, 2020, were eligible for inclusion in the study. People diagnosed with vitiligo prior to the study period (prevalent vitiligo) and people newly diagnosed with vitiligo during the study period (incident vitiligo) are included as cases.

Exclusion criteria

• People actively registered with the GP practice at that date without a history of vitiligo require a minimum one-year registration with their GP practice.

Trial design

75,771 participants in 2 patient groups

Cases

Description:

Patients with a confirmed diagnosis of Vitiligo within the study period will be included as cases for analysis.

Treatment:

Other: Exposure of skin cancer of interest

Controls

Description:

The controls will be defined by matching cases with people who have never been diagnosed with vitiligo either prior to or during the study period, by age and sex, at General Practice level.

Treatment:

Other: Exposure of skin cancer of interest