Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation (RADAR)

University Health Network, Toronto

Status

Completed

Conditions

Respiratory Failure

Mechanical Ventilation Complication

Lung Transplant; Complications, Mechanical

Diaphragm Injury

Treatments

Diagnostic Test: Ultrasound

Diagnostic Test: Respiratory function measurements

Study type

Observational

Funder types

Other

Identifiers

NCT04103996

19-5894

Details and patient eligibility

About

The study is designed to characterize the changes in diaphragm function after lung transplantation.

Full description

Diaphragm dysfunction (DD) is a well-known complication after lung transplantation. Patients with an injured and dysfunctional diaphragm have greater difficulty weaning from mechanical ventilation post-transplant - they become too weak to breathe. However, little is known about the pre-transplant predictive factors associated with diaphragm dysfunction . We have developed a new technique employing beside ultrasound to measure diaphragm thickness. This allows us to observe changes in diaphragm muscle structure and function.

The goal of the study is to determine whether pre-transplant diaphragm thickness and function are associated with diaphragmatic dysfunction after lung transplantation. This will help us to confirm the best way to avoid diaphragm injury and to understanding the meaning of diaphragm ultrasound images.

Enrollment

15 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria