Inclusive Invasive Physiological Assessment in Angina Syndromes Registry (ILIAS Registry)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status: Completed

Conditions: Coronary Artery Disease; Microvascular Coronary Artery Disease

Treatments: Diagnostic Test: Resting distal coronary to aortic pressure ratio, Fractional flow reserve, Coronary Flow Reserve, Microvascular resistance

Study type: Observational

Funder types: Other

Identifiers

NCT04485234

ILIAS Registry

Details and patient eligibility

About

This study evaluates the prognostic value and potential therapeutic impact of combined pressure and flow measurements in the evaluation of epicardial coronary stenosis and microvascular function.

Full description

ILIAS registry is a global effort to gather lesion-level data on the diagnostic and prognostic value of combined coronary pressure and flow measurements in clinical practice. Data is gathered from 7 nations (The Netherlands, Korea, Japan, Spain, Italy, Denmark, USA), using either coronary Doppler velocity measurements or coronary thermodilution measurements to obtain invasive coronary flow assessment. Patient treatment was governed by the local clinical practice guidelines at the time of the invasive procedure, but was at the operator's discretion. A standardized data collection sheet was used and all study adopted standardized definition of patient's baseline characteristics, clinical outcomes, and physiologic data. In case of acute coronary syndrome (unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction), only non-culprit vessel evaluation was used.

Enrollment: 2,322 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• underwent combined measurements of coronary pressure and flow for at least 1native coronary artery

Exclusion criteria

• hemodynamic instability
• culprit vessel of acute coronary syndrome

Trial design

2,322 participants in 1 patient group

All patients

Description:

All lesions undergo assessment with coronary pressure sensor and either Doppler velocity or coronary thermodilution

Treatment:

Diagnostic Test: Resting distal coronary to aortic pressure ratio, Fractional flow reserve, Coronary Flow Reserve, Microvascular resistance