Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa

Charité University Medicine Berlin

Status: Completed

Conditions: Anorexia Nervosa

Treatments: Other: Inpatient treatment for Anorexia nervosa

Study type: Observational

Funder types: Other

Identifiers

NCT03334032

TBN in AN

Details and patient eligibility

About

The study aimed to assess protein accretion during weight gain in adolescent patients with Anorexia nervosa

Full description

Background: Bone health and growth during adolescence require adequate Total Body Protein (TBPr). Re-nutrition for patients with anorexia nervosa (AN) should aim to normalize body composition, i.e. recovery of fat mass and TBPr.

Objective: The study intended to analyze predictors of protein status, including exercise status, in adolescents with AN, and to investigate whether weight gain would replete body protein deficits.

Methods: The investigators assessed TBPr in a longitudinal, observational study as height-adjusted nitrogen index (NI) using in-vivo neutron activation analysis in adolescents with AN at the commencement of refeeding (T0), as well as seven months thereafter (T1), and in age-matched normal weight controls. Lean tissue and fat mass were assessed with Dual-Energy X-Ray Absorptiometry (DXA). BMI, BMI-SDS and lean tissue mass were tested as predictors of protein status using Receiver Operating Characteristic (ROC) analysis.

Enrollment: 154 patients

Sex: Female

Ages: 12 to 19 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Patient Inclusion Criteria:

• diagnosis of anorexia nervosa (DSM-IV)
• aged 12 - 19 years
• female gender

Patient Exclusion Criteria:

• existence of a further disease with effect on body composition

Controls:

• no known disease
• normal weight

Trial design

154 participants in 2 patient groups

Inpatient treatment for Anorexia nervosa

Description:

Adolescents with anorexia nervosa assessed 1. at baseline: on admission to inpatient treatment 2. at follow-up: 6 months after admission on outpatient basis

Treatment:

Other: Inpatient treatment for Anorexia nervosa

Controls

Description:

Adolescent healthy and normal weight controls (matched for gender and age), assessed at one point of time