Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation

Urmia University of Medical Sciences

Status and phase: Completed; Phase 3

Conditions: Paroxysmal Atrial Fibrillation; Sick Sinus Syndrome

Treatments: Device: HBR; Device: DD

Study type: Interventional

Funder types: Other

Identifiers

NCT02317068

UMSU-Cardiology-4

Details and patient eligibility

About

This study aims to determine whether increasing atrial base rate pacing to achieve at least 75-80% atrial pacing in patients with sick sinus syndrome undergoing the implementation of dual-chamber pacemaker can be useful to prevent or decrease the atrial fibrillation during 6 months follow-up duration.

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sick sinus syndrome patients having dual-chamber pacemaker
• Having paroxysmal AF defined as at least 2 episodes of AHR/AMS >190 b/min lasting >6 minutes
• Having normal atrioventricular conduction

Exclusion criteria

• Other clinical indications for pacing except sick sinus syndrome (bradycardia-tachycardia syndrome)
• History of acute coronary syndrome
• Significant heart valve disease
• Chronic AF before randomization
• Overt heart failure
• Malignancy
• Any reasons for antiarrhythmic medication use
• Inability to follow patients every 3 months

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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200 participants in 2 patient groups

High Atrial Base Rate Pacing

Experimental group

Description:

The base rate of pacemaker will be determined 75-100 beats/minute in condition that during first step of follow-up, his/her atrial pacing will be more than 80% of atrial high rate/automatic mode switch

Treatment:

Device: HBR

Device Default

Active Comparator group

Description:

The base rate of pacemaker will be determined 60 beats/minute

Treatment:

Device: DD