Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis

Palo Alto Veterans Institute for Research

Status: Unknown

Conditions: End Stage Renal Failure on Dialysis

Treatments: Other: high dialysate flow, larger dialyzer; Other: low dialysate flow, smaller dialyzer

Study type: Interventional

Funder types: Other

Identifiers

NCT01892839

MEY0026APR

Details and patient eligibility

About

Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.

Enrollment: 24 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• stable on nocturnal in-center dialysis located close to Stanford University and VA Palo Alto

Exclusion criteria

• recent use of antibiotics
• gastrointestinal disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

high dialysate flow, larger dialyzer

Experimental group

Description:

high dialysate flow, larger dialyzer

Treatment:

Other: high dialysate flow, larger dialyzer

low dialysate flow, smaller dialyzer

Active Comparator group

Description:

low dialysate flow, smaller dialyzer

Treatment:

Other: low dialysate flow, smaller dialyzer