Increasing the Yield of Blood Cultures in Neonates

Shaare Zedek Medical Center

Status: Completed

Conditions: Bacteremia

Treatments: Other: 1cc of blood in a single aerobic culture bottle

Study type: Interventional

Funder types: Other

Identifiers

NCT01023555

SZMC-bromi

Details and patient eligibility

About

The purpose of this study is to determine whether the use of a single blood sample of 1cc in an aerobic bottle will provide a better yield and time to positivity than 2 samples of 0.5 cc in 2 (aerobic and anaerobic) bottles for blood cultures in neonates.

Enrollment: 1,500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All blood cultures taken in the NICU during the study period.

Exclusion criteria

• Bacteria that are normal flora of the skin such as Coagulase negative staphylococci or Streptococci Viridans are considered, except if grown in two sets of cultures or in the presence of laboratory and clinical indices of infection.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

1,500 participants in 2 patient groups

0.5cc 2 Bottles

No Intervention group

1cc single bottle

Active Comparator group

Treatment:

Other: 1cc of blood in a single aerobic culture bottle