Incretin Effect in Lean and Obese Subjects (BMI-INK)

University Hospital, Gentofte, Copenhagen

Status: Completed

Conditions: Insulin Resistance; Type 2 Diabetes; Incretin Effect

Treatments: Other: Isoglycemic intravenous glucose infusion; Other: Oral glucose tolerance test (OGTT)

Study type: Observational

Funder types: Other

Identifiers

NCT00803296

BMI-INK

Details and patient eligibility

About

The incretin effect is markedly reduced in patients with type 2 diabetes. Data support the notion that this deficiency is a consequence of the diabetic state. However, the impact of insulin resistance on the incretin effect in obese individuals who uphold a normal glucose tolerance (NGT) despite their insulin resistant state remains to be elucidated. The primary aim of the present study is to evaluate the separate impact of one of the cornerstones of type 2 diabetic pathophysiology, namely insulin resistance, on the incretin effect in lean and obese patients with type 2 diabetes and in two matched normal-glucose tolerant groups of healthy control subjects.

Enrollment: 32 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosed with type 2 diabetes for at least 3 months
• Normal blood hemoglobin
• Informed consent

Exclusion criteria

• Liver disease
• Diabetic nephropathy
• Treatment with medication that can not be stopped for 12 hours

Trial design

32 participants in 4 patient groups

Obese patients with type 2 diabetes

Description:

Patients with type 2 diabetes and BMI\>33

Treatment:

Other: Oral glucose tolerance test (OGTT)

Other: Isoglycemic intravenous glucose infusion

Obese subjects with normal glucose tolerance

Description:

Subjects with normal glucose tolerance and BMI\>33

Treatment:

Other: Oral glucose tolerance test (OGTT)

Other: Isoglycemic intravenous glucose infusion

Lean subjects with type 2 diabetes

Description:

Patients with type 2 diabetes and BM\<25

Treatment:

Other: Oral glucose tolerance test (OGTT)

Other: Isoglycemic intravenous glucose infusion

Lean subjects with normal glucose tolerance

Description:

Subjects with normal glucose tolerance and BM\<25

Treatment:

Other: Oral glucose tolerance test (OGTT)

Other: Isoglycemic intravenous glucose infusion