Incretin Effect in Patients With Psoriasis and Controls

University Hospital, Gentofte, Copenhagen

Status: Completed

Conditions: Psoriasis Vulgaris

Treatments: Other: Intravenous isoglycaemic glucose clamp; Other: Liquid Mixed meal test; Diagnostic Test: Oral glucose tolerance test

Study type: Observational

Funder types: Other

Identifiers

NCT06064084

11031999

Details and patient eligibility

About

To investigate the incretin effect and postprandial incretin responses in plasma in patients with psoriasis

Enrollment: 24 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

no diabetes BMI < 27 kg/m^2 normal Glucose tolerance test at screening normal fasting plasma glucose no islet auto antibodies no hormonel contraception informed consent psoriasis vulgaris (PASI>8) (case not controls)

Exclusion criteria

other chronic inflammtory skin disease other chronic inflammatory disease pregnancy psychiatric illness

Trial design

24 participants in 2 patient groups

Psoriasis

Treatment:

Other: Liquid Mixed meal test

Diagnostic Test: Oral glucose tolerance test

Other: Intravenous isoglycaemic glucose clamp

Control

Description:

Age, Sex and BMI matched

Treatment:

Other: Liquid Mixed meal test

Diagnostic Test: Oral glucose tolerance test

Other: Intravenous isoglycaemic glucose clamp