Independent and Combined Effects of Aerobic and Resistance Training on Blood Pressure (ART-B)

Iowa State University

Status: Completed

Conditions: Cardiovascular Risk Factor

Treatments: Behavioral: Aerobic Exercise; Behavioral: Combined aerobic and resistance exercise; Behavioral: Resistance Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03734146

14-330

Details and patient eligibility

About

We compared the effects of 8 weeks of aerobic exercise only, resistance exercise only, or a combination of both on blood pressure in overweight or obese middle-aged adults with elevated blood pressure. Participants engaged in supervised exercise sessions 3 times per week for 60 minutes each session. Outcomes were assessed at baseline and after the 8-week intervention. Extra-intervention physical activity and diet were also assessed.

Enrollment: 69 patients

Sex: All

Ages: 45 to 74 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systolic/diastolic blood pressure of 120-159/80-99 mm Hg
• Non-smoking
• Overweight or obese, with a body mass index of 25-40 kg/m2
• Inactive--not meeting the aerobic or resistance physical activity guidelines, which means engaging in less than 150 minutes/wk of moderate intensity aerobic exercise and less than 2 days per week of resistance training over the past 3 months.

Exclusion criteria

• Unstable coronary heart disease or decompensated heart failure
• Severe pulmonary hypertension or aortic stenosis
• Acute myocarditis, endocarditis, pericarditis, or aortic dissection
• Other medical condition that is life-threatening or that can interfere or be aggravated by the exercise training such as cancer, uncontrolled diabetes, severe pain or mobility limitations.
• Premenopausal women or postmenopausal women taking hormonal replacement therapy
• Pregnant women or anticipated pregnancy via IVF or other medical procedures during the course of the intervention

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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69 participants in 4 patient groups

Aerobic exercise (AE)

Experimental group

Description:

Engage in supervised aerobic exercise for 60 minutes on 3 days per week for 8 weeks. Exercise is performed on a recumbent bike or treadmill at 50-80% of their heart rate reserve.

Treatment:

Behavioral: Aerobic Exercise

Resistance exercise (RE)

Experimental group

Description:

Engage in supervised resistance exercise for 60 minutes on 3 days per week for 8 weeks. Exercise consists of 3 sets of 8-12 repetitions of 12 exercises for the major muscle groups.

Treatment:

Behavioral: Resistance Exercise

Combined Resistance and Aerobic Exercise

Experimental group

Description:

Engage in supervised aerobic resistance exercise for 60 minutes on 3 days per week for 8 weeks. Exercise consists of 30 min aerobic exercise at 50-80% heart rate reserve and 30 min of resistance exercise comprising 2 sets of 8-12 repetitions of 9 exercises for the major muscle groups.

Treatment:

Behavioral: Combined aerobic and resistance exercise

No training control

No Intervention group

Description:

No exercise training. Participants will refrain from any moderate-vigorous exercise or resistance training for 8 weeks.