India HIV-CervCa Project

Abramson Cancer Center at Penn Medicine

Status: Active, not recruiting

Conditions: HIV Positive; Cervical Cancer; HIV Negative

Treatments: Radiation: Radiation Therapy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT07167069

834664 (Other Identifier)

UPCC 20824

DAA3-19-65331-1 (Other Identifier)

Details and patient eligibility

About

The investigators propose to prospectively study the difference in treatment (CTRT) completion and toxicities between HIV positive and HIV negative women in India with locally advanced cervical cancer receiving CTRT.

Full description

This study will compare chemoradiation completion rates for cervical cancer in two groups, women with HIV and women without HIV. The investigators will also be analyzing tumor tissue for tumor infiltrating lymphocytes which are thought to be involved in disease progression.

Enrollment: 180 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with newly biopsy proven squamous carcinoma or adenocarcinoma of the uterine cervix, FIGO stage IB2-IIIB in whom curative CTRT is planned
• Karnofsky performance status ≥ 70
• Patients with lower paraortic lymph nodes (below the level of L2 vertebra)
• patients diagnosed with cervical cancer whom also HIV positive or HIV negative

Exclusion criteria

• patients with active tuberculosis

Trial design

180 participants in 2 patient groups

HIV Positive

Description:

Cervical Cancer Patients with HIV positive

Treatment:

Radiation: Radiation Therapy

HIV Negative

Description:

Cervical Cancer Patients with HIV negative

Treatment:

Radiation: Radiation Therapy