Indicators Predicting Surgery in Acute Severe Ulcerative Colitis(ASUC)

Gao Tao

Status: Completed

Conditions: Surgery; Ulcerative Colitis Acute

Study type: Observational

Funder types: Other

Identifiers

NCT03578692

2018NLY052

Details and patient eligibility

About

Acute severe ulcerative colitis [ASUC] patients have high risk of no response to medical treatments and might miss the best timing for surgery when waiting for the medical response. Thus, we investigated whether biomarkers which could early predict the surgery risk of patients with ASUC on admission.

Enrollment: 146 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

The inclusion criterion was patients clearly diagnosed as acute severe ulcerative colitis.

Exclusion criteria

Patients younger than 18 years-of-age, complicated with malignancy in colon and pregnant were excluded.

Trial design

146 participants in 2 patient groups

Surgery group

Description:

The protocol for patients assigned to surgery group was as follows. ASUC patients were admitted in, estimated their baseline situations and tested their blood and fecal indicators including PCT, IL-6 and FC on admission. All patients were treated according to the ECCO guideline 2012. Patients who showed bad response to medicine (glucocorticoid for 5 days and rescue therapy for 3 days) were recommended and classified in the surgery group. Their baseline manifestations were collected and compared with the medical group, to exploit the baseline indicators with great sensitive and specificity predicting the high risk for surgery.

Medical group

Description:

The protocol for patients assigned to medical group was as follows. ASUC patients were admitted in, estimated their baseline situations and tested their blood and fecal indicators including PCT, IL-6 and FC on admission. All patients were treated according to the ECCO guideline 2012. Patients who showed response to medicine (glucocorticoid for 5 days or rescue therapy for 3 days) were classified in the medical group. Their baseline manifestations were collected and compared with the surgery group.