Indices of Severity and Prognosis for Sickle Cell Disease

National Institutes of Health (NIH)

Status: Completed

Conditions: Blood Disease; Anemia, Sickle Cell

Study type: Observational

Funder types: NIH

Identifiers

NCT00005467

4912

R01HL042498 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

To develop a clinical severity index that could prospectively identify sickle cell disease patients who were at high risk for a turbulent clinical course and a poor prognosis.

Full description

DESIGN NARRATIVE:

Using the database, univariate analysis showed that factors associated with the occurrence of cerebrovascular accident (51 patients) included hematocrit, rate of change of pocked red cell count, and polymer fraction at 40 percent oxygen saturation (PF40). Only low hematocrit was predictive of death in the pediatric cohort. There were 45 disease-related deaths.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Sex: Male

Ages: Under 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

No eligibility criteria