Indirect Biomarkers and Exercise Induced Muscle Damage

Vassilis Paschalis

Status

Active, not recruiting

Conditions

Exercise Induced Muscle Damage

Treatments

Other: Eccentric Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT07503860

1858/03-10-2025

Details and patient eligibility

About

The purpose of this study is to investigate the magnitude of changes in biomarkers of exercise-induced muscle damage following an acute bout of eccentric exercise of the knee extensors performed on an isokinetic dynamometer. Moreover, these biomarkers will be assessed at different time points after the initial intervention, checking the repeated bout effect phenomenon.

Full description

Volunteers will visit the laboratory a total of two times. During the first visit, in all participants will be assessed indirect markers of exercise-induced muscle damage (i.e., peak torque, delayed-onset muscle soreness, range of motion, rate of force development), blood parameters (i.e., creatine kinase and c-Reactive Protein), and muscle oxygenation using near infrared spectroscopy. Afterwards, participants will perform an eccentric exercise protocol for the knee extensors consisting of 5 sets of 15 maximal-intensity repetitions at an angular velocity of 60°/s. The second visit will be at different time points between participant, where the indirect mauls damage biomarkers will be reassessed before and after the same isokinetic eccentric exercise (i.e., 5 sets of 15 maximal-intensity repetitions at an angular velocity of 60°/s).

Enrollment

48 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy, physically active, males

Exclusion criteria

Musculoskeletal injuries, chronic diseases, smoking, consumption of any sports/antioxidant supplements or medication, and potential inflammatory conditions