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This is a perspective, multicenter,randomized controlled trial to compare the efficacy and safety of radiotherapy Based on PET/CT and IMRT combined with concurrent chemotherapy in patients with locally advanced non small cell lung cancer . Analyses of overall survival (OS) will be done as defined in the protocol.
Full description
https://register.clinicaltrials.gov/prs/app/template/Home.vm?uid=U000184Z&ts=76&sid=S0006AP2&cx=r0ratc
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Inclusion and exclusion criteria
Inclusion Criteria:
Histologically or cytologically proven non-small cell lung cancer.
Patients must be clinical AJCC stage IIIA or IIIB (AJCC, 7th ed.) with non-operable disease; non-operable disease will be determined by a multidisciplinary treatment team.
Patients with multiple, ipsilateral pulmonary nodules (T3, or T4) are eligible if a definitive course of daily fractionated RT is planned.
Appropriate stage for protocol entry, including no distant metastases, based upon the following minimum diagnostic workup:
Serum creatinine within normal institutional limits or a creatinine clearance ≥ 60 ml/min within 2 weeks prior to registration;
The patient must provide study-specific informed consent prior to study entry.
Exclusion Criteria
Any component of small cell lung carcinoma.
Evidence of a malignant pleural or pericardial effusion .
Prior invasive malignancy (except nonmelanomatous skin cancer) in 3 years ;
Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable.
Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields;
Severe, active co-morbidity, defined as follows:
Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months; Transmural myocardial infarction within the last 6 months; Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration; Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol; Acquired Immune Deficiency Syndrome (AIDS) based upon current CDC definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is necessary because the treatments involved in this protocol may be significantly immunosuppressive. Protocol-specific requirements may also exclude immuno-compromised patients.
Pregnancy or women of childbearing potential and men who are sexually active and not willing to use medically acceptable forms of contraception.
Poorly controlled diabetes (defined as fasting glucose level > 200 mg/dL) ;
Patients with T4 disease with radiographic evidence of massive invasion of a large pulmonary artery and tumor causing significant narrowing and destruction of that artery are excluded.
Primary purpose
Allocation
Interventional model
Masking
400 participants in 2 patient groups
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Central trial contact
Jinming Yu, Ph.D , M.D; Shuanghu Yuan, Ph.D , M.D
Data sourced from clinicaltrials.gov
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