Individualized Exercise Combined With Manual Therapy in Severe Hemophilia Patients With Polyarthropathy

Far Eastern Memorial Hospital

Status: Enrolling

Conditions: Severe Hemophilia

Treatments: Other: Manual therapy combined exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06535971

FarEasternMH (Registry Identifier)

111296-E

Details and patient eligibility

About

The aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Full description

The main clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Past studies investigated the effect of manual therapy of exercise for individuals with hemophilia and found to enhance muscle strength, balance, fitness and promote quality of life. However, less study has evaluated the safety and effectiveness of manual therapy combined with exercise for individuals with multiple hemophilic arthropathy. Therefore, the aim of this study is to investigate the effect of individualized physical therapy, combined manual therapy and exercise intervention, for pain perception, range of motion (ROM), muscle strength, joint health, cardiopulmonary endurance and quality of life (QoL) in patients with severe hemophilia A and multiple hemophilic arthropathy.

Enrollment: 10 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• over 20 years old and diagnosed with severe hemophilia
• those who receive prophylaxis regularly
• there are more than 2 target joints (hemophilic arthropathy)

Exclusion criteria

• unwilling to sign the informed consent
• any neurological disease or specific musculoskeletal condition (such as fracture) one year ago
• more than 3 (excluding 3) joint replacement surgeries (different joints)
• unable to walk due to hemophilia joint disease or any other diseases
• major bleeding events that pose risks or hinder research
• unable to follow instructions due to cognitive impairment

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

10 participants in 1 patient group

Physiotherapy group

Other group

Description:

Individualized physiotherapy intervention based on manual therapy and exercise 1 session per week for 3 months

Treatment:

Other: Manual therapy combined exercise