Individualized Intraoperative PEEP Following Alveolar Recruitment Maneuvres and Postoperative Respiratory Complications

Asklepieion Voulas General Hospital

Status and phase: Completed; Phase 2

Conditions: Postoperative Respiratory Complications

Treatments: Other: Standard PEEP; Other: Alveolar recruitement

Study type: Interventional

Funder types: Other

Identifiers

NCT06600386

10542/22-05-2024/AP51

Details and patient eligibility

About

Patients ASA I-III, undergoing laparoscopic abdominal surgery will be randomly assigned, into one of two groups, namely group C-PEEP , that will be the control group ; and group I-PEEP, where alveolar recruitment maneuvres will take place in order to identify each patient's individualized optimal PEEP. All patients will receive a standardized anesthesia regimen. The lung ultrasound score will be evaluated in all patients in the PACU and then respiratory complications will be recorded on the 24th hour, 48th hour, 7th day and 30the day, postoperatively.

Enrollment: 69 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

ASA I-III Laparoscopic abdominal surgery

Exclusion criteria

Severe kidney dysfunction Severe hepatic dysfunction Severe respiratory disease Severe cardiac disease Severe neuromuscular disease BMI>30 Severe intraoperative hemorrage Severe intraoperative hemodynamic instability

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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69 participants in 2 patient groups

C-PEEP

Active Comparator group

Description:

PEEP is standard (5cmH2O)

Treatment:

Other: Standard PEEP

I-PEEP

Active Comparator group

Description:

PEEP is individualized following standard recruitment maneuvres

Treatment:

Other: Alveolar recruitement