Individualized PEEP Setting by EIT in Patients With ARDS

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: the PEEP Setting of ARDS

Treatments: Other: the EIT guide the individualized PEEP Setting

Study type: Interventional

Funder types: Other

Identifiers

NCT02361398

PUMCH-ARDS-EIT

Details and patient eligibility

About

The investigators conducted a pilot study to compare the effect of Positive End Expiratory Pressure(PEEP) setting guide by lung electrical impedance tomography(EIT) and ARDS-net PEEP-FiO2 table on survival in subjects with mild/severe Acute Respiratory Distress Syndrome(ARDS).

Enrollment: 126 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion:

1. acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)<300 and PEEP >5cmH2O
2. Body mass index < =40
3. Written inform consent

Exclusion:

1. pregnant，intracranial hypertension
2. left ventricular dysfunction (EF<25% )
3. Patients with end-stage conditions(death expected within 90 days)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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126 participants in 2 patient groups

EIT group

Experimental group

Description:

the Individualized PEEP titration by EIT was administered to the patients in the EIT group.

Treatment:

Other: the EIT guide the individualized PEEP Setting

control group

No Intervention group

Description:

If patients are assigned to the control group, the Individualized PEEP Setting was by PEEP-FiO2 table based on ARDS-net protocol.