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Individualized Precise Localization of rTMS on Precentral and Parietal Gyrus

H

Hangzhou Normal University

Status

Completed

Conditions

Attention Deficit Hyperactivity Disorder

Treatments

Device: rTMS

Study type

Interventional

Funder types

Other

Identifiers

NCT03515408
HZNU_sustainded_attention_rTMS

Details and patient eligibility

About

Attention deficit hyperactivity disorder (ADHD) patients have some problem with sustained attention. The dorsal anterior cingulate cortex (dACC) plays a key role for attention control. It has been found that the dACC has strong functional connectivity with ipsilateral motor area and parietal gyrus. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of sustained attention, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and parietal gyrus, and combining rTMS to activate the dACC.

Full description

Healthy subject is recruiting in this project. High rTMS will be performed. The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).

Enrollment

32 patients

Sex

All

Ages

19 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • There are activation in dACC, motor area and parietal gyrus during the task fMRI
  • The head motion less than 2 mm in translation or 2 degrees in rotation in any direction during the resting-state fMRI

Exclusion criteria

  • Without any neuropsychiatric conditions
  • No head injury or history of epilepsy
  • Not on any medications

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

32 participants in 4 patient groups

Real rTMS (motor area)
Experimental group
Description:
Real rTMS targeting motor area for 30 min
Treatment:
Device: rTMS
Real rTMS (parietal gyrus)
Experimental group
Description:
Real rTMS targeting parietal gyrus for 30 min
Treatment:
Device: rTMS
Real rTMS (both brain area)
Experimental group
Description:
Real rTMS targeting motor area and parietal gyrus for 15 min, separately
Treatment:
Device: rTMS
Sham rTMS
Sham Comparator group
Description:
Sham rTMS targeting motor area and parietal gyrus for 15 min, separately
Treatment:
Device: rTMS

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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