Individualized Precise Localization of rTMS on Precentral and Parietal Gyrus

Hangzhou Normal University

Status: Completed

Conditions: Attention Deficit Hyperactivity Disorder

Treatments: Device: rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT03515408

HZNU_sustainded_attention_rTMS

Details and patient eligibility

About

Attention deficit hyperactivity disorder (ADHD) patients have some problem with sustained attention. The dorsal anterior cingulate cortex (dACC) plays a key role for attention control. It has been found that the dACC has strong functional connectivity with ipsilateral motor area and parietal gyrus. Repetitive Transcranial Magnetic Stimulation (rTMS) is a sage and painless technique to activate cortical areas. The deep brain structure can be activated via stimulating superficial cortex by rTMS. For investigating the mechanism of sustained attention, this project is using functional magnetic resonance imaging (fMRI) to individualize the precise localization in motor area and parietal gyrus, and combining rTMS to activate the dACC.

Full description

Healthy subject is recruiting in this project. High rTMS will be performed. The 10-Hz stimulation is delivered at 100% of the subject's resting motor threshold via 60 trains of 3-s 10-Hz rTMS (30 pulses with 27-s duration per train).

Enrollment: 32 patients

Sex: All

Ages: 19 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• There are activation in dACC, motor area and parietal gyrus during the task fMRI
• The head motion less than 2 mm in translation or 2 degrees in rotation in any direction during the resting-state fMRI

Exclusion criteria

• Without any neuropsychiatric conditions
• No head injury or history of epilepsy
• Not on any medications

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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32 participants in 4 patient groups

Real rTMS (motor area)

Experimental group

Description:

Real rTMS targeting motor area for 30 min

Treatment:

Device: rTMS

Real rTMS (parietal gyrus)

Experimental group

Description:

Real rTMS targeting parietal gyrus for 30 min

Treatment:

Device: rTMS

Real rTMS (both brain area)

Experimental group

Description:

Real rTMS targeting motor area and parietal gyrus for 15 min, separately

Treatment:

Device: rTMS

Sham rTMS

Sham Comparator group

Description:

Sham rTMS targeting motor area and parietal gyrus for 15 min, separately

Treatment:

Device: rTMS