Individualized rTMS Based on fNIRS to Spasticity

Xi'an Jiaotong University

Status: Unknown

Conditions: Spasticity, Muscle; Rehabilitation; Stroke

Treatments: Procedure: individual rTMS based on fNIRS; Procedure: Traditional rTMS strategy

Study type: Interventional

Funder types: Other

Identifiers

NCT05318586

2022JQ-982

Details and patient eligibility

About

Stroke is of high morbidity and mortality, and surviving patients are often unable to take care of themselves because of severe motor dysfunction. The brain has plasticity, and makes adaptive changes after stroke, resulting in the reorganization and compensation of neural networks. However, the muscle tone of some patients will significantly increase during the recovery process, which affects the rehabilitation effect. Neuromodulation techniques such as repetitive transcranial magnetic stimulation (rTMS) have been widely used to promote brain network remodeling after stroke. The investigators attempted to evaluate the motor brain network characteristics of spastic patients by fNIRS, and used the most active brain regions as rTMS stimulation regions to evaluate the improvement effect of this individualized treatment on post-stroke spasticity.

Enrollment: 20 estimated patients

Sex: All

Ages: 40 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 40-79 years;
• Patients with first-onset stroke within 1 to 3 months after onset;
• Consciousness, sitting balance level 1 or above, can cooperate with fNIRS assessment;
• The patient or its authorized agent signs the informed consent form.

Exclusion criteria

• Previous seizures;
• Suffered from mental illness such as depression, anxiety, mania, and schizophrenia before the stroke onset;
• Patients with metal on the head, cochlear implants, intracranial infections, etc. who are not suitable for rTMS.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Individualized rTMS based on fNIRS

Experimental group

Description:

Low-frequency rTMS will be given to the most active brain regions assessed by fNIRS.

Treatment:

Procedure: individual rTMS based on fNIRS

Traditional rTMS strategy

Active Comparator group

Description:

The control group will always be given low-frequency rTMS to contralesional M1

Treatment:

Procedure: Traditional rTMS strategy