Individualized Strategies of Red Blood Cell Transfusion for Perioperative Pediatric Patients

Fudan University

Status: Withdrawn

Conditions: Individualized Transfusion Strategy; Clinical Outcome; Perioperative Pediatric Patient; Red Blood Cell

Treatments: Diagnostic Test: clinical condition score

Study type: Interventional

Funder types: Other

Identifiers

NCT04537000

transfusion-08-2020

Details and patient eligibility

About

The individualized strategies of red blood cell for perioperative pediatric patients are made based on the comparison between the clinical condition score and the Hb concentration.

Full description

The hypothesis is that the individual transfusion strategies will help to save blood resource, and meanwhile will not adversely affect the patients' clinical outcomes. Participants will be randomly divided into two groups, where the strategies of transfusion of red blood cell will be made following different principles. The strategies for patients in control group will be made by the attending doctors in charge according to the current Chinese red blood cell transfusion guidelines. For the patients in study group, the clinical condition will be identified every time red blood cell transfusion is considered. The strategies will be made according to the comparison between the score and the Hb concentration. The volume of the red blood cell used in these two groups will be compared. The number of patients who need transfusion in these two groups will be compared. The clinical outcomes will also be compared between the two groups.

Sex: All

Ages: 1 month to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The Hb concentration is tested before operation. It is higher than 7g/dl and lower than 10g/dl. Or it is anticipated that it will decrease lower than 10g/dl.

Exclusion criteria

• The patient will not undergo an operation.
• newborn or premature baby
• patients accompanied with hemorrhagic disease or cyanotic heart disease
• patients with ischemic heart disease or ischemic cerebrovascular disease

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups

control group

No Intervention group

Description:

The strategies of red blood cell transfusion for the pediatric patients in this group will be made by the attending doctors in charge based on the current transfusion guidelines. The attending doctors decide when to start blood red cell transfusion and order the volume of the blood red cell as the usual clinical practice.

study group

Experimental group

Description:

For study group, the clinical condition score must be identified every time red blood cell transfusion is considered. The strategies of red blood cell transfusion for the pediatric patients in this group, including the trigger and the volume, will be made based on the comparison between the clinical condition score and the Hb concentration.

Treatment:

Diagnostic Test: clinical condition score