Individualizing tDCS Dose

Medical University of South Carolina (MUSC)

Status: Withdrawn

Conditions: Motor Function; tDCS

Treatments: Device: 4mA transcranial direct current stimulation; Device: Individualized transcranial direct current stimulation; Device: 2mA transcranial direct current stimulation; Device: Sham transcranial direct current stimulation

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04742439

00104712

P2CHD086844 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Transcranial direct current stimulation (tDCS) is a noninvasive method of modulating brain activity and has therapeutic potential in many neurological and psychiatric conditions. However, unlike every current FDA-approved form of brain stimulation, there is no method of individualizing stimulation dose. In this study, a method of individualizing tDCS dose on behavioral outcomes and whether this could help to improve the consistency and magnitude of the stimulation effects will be tested.

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers or chronic stroke participants (at least 6 months prior to the study)
• No history of epilepsy
• No metal in the body
• No contraindications for TMS or MRI scanning
• Right handed
• Ability to find motor hotspot and acquire motor evoked potentials

Exclusion criteria

• Metal in the body
• History of epilepsy or claustrophobia
• Alcohol or substance abuse or dependence
• Current treatment for any psychiatric conditions (pharmacological or otherwise)
• Pregnant or actively breastfeeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

---

0 participants in 4 patient groups

Sham stimulation

Sham Comparator group

Treatment:

Device: Sham transcranial direct current stimulation

Individualized stimulation

Experimental group

Treatment:

Device: Individualized transcranial direct current stimulation

2mA stimulation

Experimental group

Treatment:

Device: 2mA transcranial direct current stimulation

4mA stimulation

Experimental group

Treatment:

Device: 4mA transcranial direct current stimulation