Indocyanine Green (ICG) and SPY Imaging for Assessment of Burn Healing

Texas Tech University Health Sciences Center

Status: Completed

Conditions: Burns

Treatments: Device: ICG/SPY; Drug: Antibiotic Ointment

Study type: Interventional

Funder types: Other

Identifiers

NCT02766244

003 NCT02028520

Details and patient eligibility

About

Three patients were recruited for assessment of ICG fluorescence in burns.

Full description

The early determination of healing potential in indeterminate thickness burns may be difficult to establish by visual inspection alone, even for experienced burn practitioners. This case series explores the use of indocyanine green (ICG) fluorescence using portable bedside assessment as a potential tool for early determination of burn depth. Three subjects with indeterminate thickness burns had daily perfusion assessment using ICG fluorescence assessment using the SPY machine (SPY®, Lifecell Corp., NJ, USA) in addition to standard burn care. The fluorescence was quantified as a percentage of the perfusion of intact skin, and areas of hypo and hyper-perfusion were indicated. The burn surgeon, blinded to the ICG results, made a clinical determination of the need for skin grafting or discharge. The perfusion in areas of differing depth of burn were compared over the entire study period to determine both the magnitude of difference, and the point in the time course of healing when these changes became evident.

Enrollment: 3 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with burn less than 15% TBSA

Exclusion criteria

• none

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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3 participants in 1 patient group

ICG/SPY

Experimental group

Description:

Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence.

Treatment:

Device: ICG/SPY

Drug: Antibiotic Ointment