Indomethacin Prior to Difficult Embryo Transfer is it a Solution?

Cairo University (CU)

Status and phase: Completed; Phase 3

Conditions: Difficult Embryo Transfer

Treatments: Procedure: IVF/ICSI; Drug: Indomethacin 100Mg Suppository

Study type: Interventional

Funder types: Other

Identifiers

NCT03533803

12018

Details and patient eligibility

About

IVF/ICSI patients who had difficult mock embryo transfer on the day of ovum pick up. Will be randomly assigned into two groups; group A will receive 100mg indomethacin rectal suppository 1-2 hours before ET and group B will not receive indomethacin

Enrollment: 200 patients

Sex: Female

Ages: 20 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Infertile patients undergoing IVF cycle with difficult mock embryo transfer
• Early follicular FSH level ≤10 IU/L.
• Tubal, male infertility and unexplained causes of fertility will be recruited.
• Fresh ET.

Exclusion criteria

• Repeated IVF failure.

• Past history of allergy to NSAID, bronchial asthma , peptic ulcer or inflammatory bowel disease.

  • Easy mock embryo transfer.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

200 participants in 2 patient groups, including a placebo group

Group A (Indomethacin)

Active Comparator group

Description:

All patient had long stimulation protocol and IVF/ICSI. After mock embryo transfer women with any degree of difficulty will receive Indomethacin 100Mg Suppository 1-2 hours before embryo transfer.

Treatment:

Procedure: IVF/ICSI

Drug: Indomethacin 100Mg Suppository

Group B (Control)

Placebo Comparator group

Description:

All patient had long stimulation protocol and IVF/ICSI. After mock embryo transfer women with any degree of difficulty will not receive any medications before embryo transfer.

Treatment:

Procedure: IVF/ICSI