Indoor Air Filtration and Young Adults Health Study

Peking University

Status: Completed

Conditions: Cardiopulmonary Diseases

Treatments: Other: Air purifier

Study type: Interventional

Funder types: Other

Identifiers

NCT05172388

IRB00001052-21109

Details and patient eligibility

About

This study aims to explore the cardiopulmonary health effects of indoor air purification and other indoor environmental conditions among young healthy college students in Beijing, China.

Full description

The present randomized, double-blind crossover study was conducted to investigate the cardiopulmonary health effects of air purification among 81 young healthy college students in Beijing, China. Real or sham purification was performed in the dormitories for 4 days, following a 15-day wash-out period in the intervals. During the study periods, the investigators collected indoor exposure levels of size-fractionated particulate matter (PM), black carbon (BC), noise, ozone, nitrogen dioxide, carbon dioxide, volatile organic compounds, temperature, relative humidity, illumination, and microorganism. Biological specimens (i.e., morning urine, fasting venous blood, exhaled breath condensate, and nasal mucus) were also collected and examined. Some important individual factors including demographical information (age, sex, height, weight, etc.), physical activity, sleep condition, mood and cognition, and food intake were also gathered using questionaire or anthropometric measurements, in order to control for the potential confounding effects. For further data analyses, air pollutants, noise, and other exposures would be controlled as confounders when addressing the health effects associated with air purification, and would also be used to explore their effects on cardiopulmonary health. The interaction effects of air pollutants, noise, and other exposures on cardiopulmonary health would also be explored.

Enrollment: 81 patients

Sex: All

Ages: 18 to 28 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Living in Beijing for more than one consecutive years;
• College students between 18-28 years;

Exclusion criteria

• Current or past smokers;
• Body mass index (BMI) over 28.0 kg/m2.
• Alcohol addict;
• Having thoracic surgery history;
• History of diagnosed chronic disease;
• Hepatitis B / hepatitis C virus patient / carrier;
• Unwilling or unable to provide informed consent or cooperate with all research related procedures.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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81 participants in 2 patient groups

Real purification

Active Comparator group

Description:

Air purifier turned on.

Treatment:

Other: Air purifier

Sham purification

Sham Comparator group

Description:

Air purifier turned off.

Treatment:

Other: Air purifier