Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia

Mass General Brigham

Status: Completed

Conditions: Ventricular Tachycardia

Treatments: Drug: Fentanyl; Drug: Propofol; Drug: Sevoflurane; Drug: Versed

Study type: Interventional

Funder types: Other

Identifiers

NCT02419547

2013-P-000241

Details and patient eligibility

About

This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure.

Data collected during this research study will help electrophysiologists and anesthesiologists to make the best decisions about the best anesthetic conditions to use to perform VT ablations.

This research study is a "pilot" study. Pilot studies are done on a small group of subjects to learn if a larger study would be useful.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with VT and have an implanted ICD who are scheduled for VT catheter ablation.
• Patients 18 years of age or older

Exclusion criteria

• Patients with difficult airway management or patients with contra/ relative contra indication for general anesthesia or known allergies to any of the proposed anesthetic agents
• Women who are pregnant

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Anesthesia Induction

Other group

Description:

Patients undergoing ventricular tachycardia ablation will undergo programmed stimulation (PS) with minimal sedation (Versed, Fentanyl), with intravenous agents (propofol) , and finally with volatile inhalational agent (sevoflurane).

Treatment:

Drug: Versed

Drug: Sevoflurane

Drug: Propofol

Drug: Fentanyl