Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation (INTENS)

Heidelberg University

Status: Unknown

Conditions: Blood Pressure, Low

Treatments: Drug: Sevoflurane; Drug: Midazolam; Drug: Etomidate

Study type: Observational

Funder types: Other

Identifiers

NCT04934410

S-602/2020

Details and patient eligibility

About

The induction of anesthesia is one of the most critical situations for high-risk-patients undergoing major surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase.

This observational study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of antihypotensive drugs during the induction and the surgical procedure in heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD).

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Heart failure patients scheduled for implantation of left ventricular assist device (LVAD)

Exclusion criteria

• Pregnancy
• Presence of another cardiac assist device in the patient (for example ECLS)
• No consent of the patient

Trial design

50 participants in 3 patient groups

Patients undergoing Implantation of left ventricular assist device (Etomidate)

Description:

High-risk heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD). The induction agent is etomidate.

Treatment:

Drug: Etomidate

Patients undergoing Implantation of left ventricular assist device (Midazolam)

Description:

High-risk heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD). The induction agent is midazolam.

Treatment:

Drug: Midazolam

Patients undergoing Implantation of left ventricular assist device (Sevoflurane)

Description:

High-risk heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD). The induction agent is sevoflurane.

Treatment:

Drug: Sevoflurane