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The benefit of induction chemotherapy followed by chemoradiotherapy for locally advanced head and neck squamous cell carcinoma is unknown. The present study is investigating if this therapeutic strategy improve overall survival.
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Inclusion criteria
Confirmed histological diagnosis of squamous cell carcinoma or undifferentiated carcinoma of the oropharynx, hypopharynx or larynx;
Locally advanced stage (stage IVa / b - AJCC 8th edition), classified as resectable ** or unresectable and candidate for treatment based on radiotherapy and chemotherapy;
Locally advanced stage (stage III - AJCC 8th edition), classified as resectable or unresectable, positive p16 and candidate for treatment based on radiotherapy and chemotherapy;
It will be allowed to include a patient with cervical lymphadenectomy if the primary lesion is measurable;
Presence of measurable disease according to RECIST 1.1 criteria;
ECOG performance status of 0-1;
≥ 18 years;
Adequate marrow reserve indicated by:
Adequate renal and hepatic function:
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
434 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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