Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest
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About
The overall goal of this study is to determine whether initiating hypothermia in cardiac arrest patients as soon as possible in the field results in a greater proportion of patients who survive to hospital discharge compared to standard prehospital/field care.
Full description
In this study we will randomize 1,200 cardiac arrest patients who have return of spontaneous circulation (ROSC) to hypothermia with rapid infusion of 2 liters of 4oC Normal Saline IV solution over 20 to 30 minutes, IV sedation and muscle paralysis or to standard of care following ROSC.
The primary objective of this study will be to determine whether induction of mild hypothermia using an infusion of cold normal saline will improve the proportion of patients who survive and are discharged awake from the hospital.
Hypothesis: In cardiac arrest patients who achieve ROSC in the field, initiation of hypothermia by infusion of cold normal saline will result in a greater proportion of cardiac arrest patients discharged awake from the hospital compared to standard care.
Enrollment
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Inclusion criteria
- successful resuscitation from out-of-hospital cardiac arrest by paramedics, defined by having a palpable pulse
Exclusion criteria
- traumatic cause for cardiac arrest
Trial design
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Interventional model
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1,359 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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