Induction of Ovulation Using Clomiphene Citrate and N-acetyl Cysteine Versus Letrozole

Assiut University

Status and phase: Completed; Phase 3

Conditions: Infertility

Treatments: Drug: Letrozole; Drug: Clomiphene Citrate plus N acetyl cystine

Study type: Interventional

Funder types: Other

Identifiers

NCT03241472

NACLET

Details and patient eligibility

About

Infertility is defined as a couple's inability to become pregnant after one year of unprotected intercourse in women 35 years old and younger, and for six months in women over age 35 years. In any given year, about 15 percent of couples in North America and Europe who are trying to conceive are infertile

Enrollment: 100 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All primary and secondary. Infertility due to anovulation

Exclusion criteria

• Male factor infertility, tubal factor.
• Endocrineopathy
• Hypothyrodism
• Morbid obesity
• Under weight
• Patient with previous surgery including drilling of ovary, Clomiphene Citrate resistant to ovulation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

100 participants in 2 patient groups

Lertozole

Experimental group

Description:

oral tablets 5 mg start from third day cycle for 5 days

Treatment:

Drug: Letrozole

clomiphene plus N- acetyl cystiene

Active Comparator group

Description:

clomiphene 100 mg plus N-acetyl cystiene 600 mg start from third day cycle for 5 days

Treatment:

Drug: Clomiphene Citrate plus N acetyl cystine