Infection Prevention After TKA With or Without Vancomycin (TKA_Vanco)

Centre of Postgraduate Medical Education

Status: Enrolling

Conditions: Infection

Treatments: Procedure: Knee arthroplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT05461651

TKA

Details and patient eligibility

About

Prospective, Randomized, Double Blinded Trial Comparing Clinical, Radiological and Laboratory Outcomes in prevention of infection after Total Knee Arthroplasty With or Without Vancomycin.

Full description

Infection after surgery is one of the most common complication after total knee replacement. Our prospective randomized study is intended to show if addition of vancomycin to the joint before the wound closure will decrease infection after operation.

Enrollment: 1,800 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Gosnartrosis

Exclusion criteria

• no informed consent to participate in the study age under 40 multilligament injury or single plane knee instability another musculoskeletal disorders in lower limb ASA score > II

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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1,800 participants in 2 patient groups

Knee arthroplasty

Sham Comparator group

Description:

Knee arthroplasty without addition of antibiotic wash oraz antibitiotic powder to the surgery site

Treatment:

Procedure: Knee arthroplasty

Knee arthroplasty + vancomycin

Active Comparator group

Description:

Knee arthroplasty with addition of vancomysin powder to the surgery site

Treatment:

Procedure: Knee arthroplasty