Infections and Latent Autoimmune Diabetes in Adults (LADA)

Karolinska Institute

Status: Completed

Conditions: Latent Autoimmune Diabetes in Adults; Type 2 Diabetes

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT06167616

2022-00811_1

2018-00337 (Other Grant/Funding Number)

NNF19OC0057274 (Other Grant/Funding Number)

2018-03035 (Other Grant/Funding Number)

Details and patient eligibility

About

Infections are proposed risk factors for type 1 diabetes in children. The investigators will examine whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults.

Full description

The investigators will use data from a population-based Swedish case-control study (ESTRID) with incident cases of LADA (n=597) and matched controls (n=2386). History of infectious disease are ascertained through national and regional patient registers. The investigators will estimate adjusted odds ratios (OR) with 95% CI for ≥1 respiratory (any/upper/lower), gastrointestinal, herpetic, other or any infectious disease episode, or separately, for 1 and ≥2 infectious disease episodes, within 0-1, 1-3, 3-5 and 5-10 years before LADA diagnosis/matching. Stratified analyses will be performed based on HLA risk genotypes and GADA levels.

Enrollment: 5,048 patients

Sex: All

Ages: 35+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 35 years or older, residing in Scania or Uppsala county.

Exclusion criteria

• Less than 35 years

Trial design

5,048 participants in 3 patient groups

LADA

Description:

Classification of LADA based on age ≥35 years at diagnosis, GADA positivity (≥10 U/ml) and C-peptide concentrations of ≥0.2 nmol/L (IMMULITE) or ≥0.3 nmol/L (Cobas).

Type 2 diabetes

Description:

≥35 years, GADA negative and C-peptide concentrations of \>0.60 (IMMULITE)/\>0.72 (Cobas) nmol/L.

Controls

Description:

≥35 years, free of diabetes