Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France (ARBT21)

Centre Hospitalier Sud Francilien

Status: Completed

Conditions: Down Syndrome

Treatments: Other: lower respiratory tract disease

Study type: Observational

Funder types: Other

Identifiers

NCT06336577

2024/0003

Details and patient eligibility

About

The purpose of this study is to describe infectious and non-infectious lower respiratory tract diseases in children with Down syndrome followed in pediatric pulmonology consultations in Ile de France.

Full description

Down syndrome is the most common chromosomal abnormality, affecting 600 to 800 births per year. It results in a clinical picture that combines developmental delay, mental deficiency, facial dysmorphism and visceral malformations.

Optimal medical care of Down syndrome patients requires a good knowledge of the different systems affected by the disease, particularly respiratory damage.

Numerous articles have been published describing upper respiratory problems in children with Down syndrome. On the other hand, lower respiratory problems causing significant morbidity and mortality remain underestimated and poorly understood in this population.

The objective of this study is to describe lower respiratory problems in patients with T21, in order to improve their management.

This study will also make it possible to describe more precisely the impact that these attacks have on Down syndrome patients.

This study also describe the associated extra-respiratory disorders to improve overall care Finally, the respiratory care of these patients will be described, with the aim of standardizing practices.

Enrollment: 108 patients

Sex: All

Ages: 1 day to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Child from 0 to 17 years old
• Carrier of Down syndrome confirmed by karyotype
• Having had follow-up in a pediatric pulmonology consultation for an infectious or non-infectious lower respiratory tract
• Not exclusively presenting upper respiratory otorhinolaryngological damage

Exclusion criteria

• Patient under guardianship or curators
• Adult or holders of parental authority informed of the study and having objected to it