Infertility and Endometriosis Cohort (EndoFertil)

University Hospital Center (CHU)

Status: Unknown

Conditions: Infertility; Endometriosis

Treatments: Other: live birth date and quality of life assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT01833013

9113

Details and patient eligibility

About

Nowadays, one in six couples consults for fertility problems. If the standard examination and tests do not reveal any cause of infertility, the woman may undergo a laparoscopic exploration which reveals endometriosis in more than 50% of cases.

Endometriosis is an inflammatory disease defined as the presence of endometrial tissue out of the uterine cavity. It is frequent (1 in 10 women) and associated with a high economic burden (22 billion dollars in 2002 in the USA) and important decrease in quality of life. Physiopathological mechanisms and risk factors for endometriosis are not well identified.

A woman with endometriosis is 20 times more at risk of infertility. Fecundity rate of a 25-year-old couple is about 15 to 20% in the general population and only 2 to 10% in case of endometriosis.

There are many manifestations of this disease (infertility, pelvic pain) and the anatomo-clinical correlation is not good. The presently used international classification (American Fertility Society revised in 1985, AFSr) does not predict the chance of pregnancy. New scores such as the Endometriosis Fertility Index (EFI) have been proposed to do so, but need to be validated. Treatment for endometriosis-related infertility is not consensual.

A prospective cohort study would give access to clinical data of patients followed in our center, so as to identify clinical factors predicting pregnancy and to help treatment decision for women with endometriosis suffering from infertility.

Enrollment: 200 estimated patients

Sex: Female

Ages: 18 to 41 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Woman from 18 to 41 years old.
• Dealing with infertility,
• With a normal pelvic echography and hysterosalpingography, a normal hormonal status and a partner with a normal sperm.
• For whom a laparoscopic exploration finds endometriosis.
• Consenting to participate to the study.

Exclusion criteria

• Any contraindication for general anesthesia or for laparoscopy.
• Any contraindication for pregnancy.
• Follow-up is impossible.
• Consent is impossible.

Trial design

200 participants in 1 patient group

endometriosis cohort

Other group

Description:

females suffer from endometriosis

Treatment:

Other: live birth date and quality of life assessment