Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage

National Cheng-Kung University

Status

Enrolling

Conditions

Inflammation

Obesity

Study type

Observational

Funder types

Other

Identifiers

NCT04275674

A-ER-105-481

Details and patient eligibility

About

The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation. Obesity is associated with an increased risk of recurrent miscarriage (RM), but the underlying mechanisms are unclear. Abnormal inflammasome activation was also identified in the endometrium of women who experienced RM. Given inflammasome activation has emerged as common pathophysiology in obesity-related disorder and RM, the investigators wonder whether inflammasome activation occurs in the uterine macrophages of obese women, and result in early reproductive failure.

Full description

pending

Enrollment

57 estimated patients

Sex

Female

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

All women have conceived naturally without the aid of assisted reproductive technologies