Inflammation and Cellular Immunity in Vaginal Tissue in Patients With Pelvic Organ Prolapse

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Pelvic Organ Prolapse

Treatments: Procedure: Colporrhaphy; Procedure: Hysterectomy

Study type: Observational

Funder types: Other

Identifiers

NCT03748693

HYMC-0073-18

Details and patient eligibility

About

The aim of this study is to investigate the inflammatory and maturation processes of immature myeloid cells (IMC) in the vaginal tissue in women with advanced pelvic organ prolapse (POP) (stage III-IV) and in normal non-POP controls.

We hypothesize that the processes contributing to POP may be related to immune response and changes in myeloid cell populations and the cytokine environment.

Enrollment: 20 estimated patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women with POP undergoing colporrhaphy
• Women undergoing hysterectomy

Exclusion criteria

• Autoimmune and connective tissue disorders
• Cancer in genital tract

Trial design

20 participants in 2 patient groups

POP Group

Description:

Women with POP undergoing surgery in our OB/GYN department.

Treatment:

Procedure: Colporrhaphy

Non-POP Group

Description:

Women undergoing hysterectomy for other indications.

Treatment:

Procedure: Hysterectomy