Inflammation and Obesity-associated Disease (Adipos2)

Göteborg University

Status: Enrolling

Conditions: Inflammation; Cardiometabolic Syndrome; Obesity; Fibrosis; Metabolic Syndrome; Liver Disease; Kidney Disease

Treatments: Procedure: Laparoscopic surgery

Study type: Observational

Funder types: Other

Identifiers

NCT02322073

682-14

Details and patient eligibility

About

Visceral obesity and adipose inflammation is considered a driving force of obesity-related systemic disease, e.g. cardiometabolic disease, liver cirrhosis and chronic kidney disease (CKD). Inflammatory resolution is actively regulated by specialized pro-resolving mediators (SPMs), including the endogenous eicosanoid LXA4. Impairment of SPMs may underlie development of obesity-related pathology.We hypothesize that obese patients who develop obesity-related disease do so because they suffer from impaired endogenous production of pro-resolving lipids. This will result in aggravated adipose inflammation and fibrosis, which contribute to the systemic pathologies. We thus wish to investigate adipose inflammation and the pro-resolving lipid profile of obese subjects with and without obesity associated metabolic disease. We also aim to investigate whether LXA4, LXB4 and other anti-inflammatory agents (such as AICAR) can alter the phenotype of human adipose macrophages in ex vivo tissue culture. We also investigate basic pathways in inflammatory regulation and obesity related cardiometabolic disease.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Obese BMI 35-55 kg/m2
• Lean BMI 18.5-24.9

Exclusion criteria

• Medical treatment with NSAIDs, corticosteroid treatment, immune-suppressants.
• Other: smoking, alcohol abuse.

Trial design

80 participants in 2 patient groups

Lean healthy controls

Description:

Healthy controls with BMI 18.5-24.9 Laparoscopic surgery eg cholecystectomy, fundoplication or Heller myotomy and fundoplication or laparoscopic hernia repair.

Treatment:

Procedure: Laparoscopic surgery

Obese

Description:

Obese BMI 35-55 Laparoscopic Roux-en-Y gastric bypass or Sleeve gastrectomy Phenotype according to cardiometabolic status