Inflammation and Organ Impact During Hepatic Surgery

Sahlgrenska University Hospital

Status: Completed

Conditions: Hepatic Surgery

Treatments: Procedure: elective surgery, according to deprtement routine

Study type: Observational

Funder types: Other

Identifiers

NCT03878615

Dnr740-18

Details and patient eligibility

About

Monitoring of inflammatory substances (such as interleukins, CRP, albumine), and markers of organ dysfunction (such as creatinine, proenkephaline, amylase, troponine, IFABP and lactate) during elective liver resection. The study also includes monitoring of hemodynamic parameters, blood loss and postoperative complications. Results are to be used för power calculation for future trials.

Full description

During hepatic surgery, blood and urine samples will be obtained at 3 times during surgery, at 3 h after resection of liver, at 24 h after resection of liver and at post operative day 2, and subsequntly analyzed for the above mentioned substances. Routine labs will be monitored until patient is discharged from hospital. During surgery, hemodynamic parameters will be monitored by Picco calculations. Urine output and blood loss will be registred.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

ASA I-III Patient has given informed consent to participate in study.

Exclusion criteria

preoperative kidney failure (E-GFR >30), current infection treatment with corticosteroids coagulopathy surgical or anatomical conditions that makes patient unsuitable for participation (for example reoperation, need of vascular bypass, single tumor)

Trial design

18 participants in 1 patient group

Elective Hepatic Surgery

Description:

Patientes undergoing elective hepatic resection, managed according to departement routine.

Treatment:

Procedure: elective surgery, according to deprtement routine