Inflammation and the Heart

Vanderbilt University

Status: Completed

Conditions: Rheumatoid Arthritis

Treatments: Other: cardiac Magnetic Resonance imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT01589770

120314

Details and patient eligibility

About

Studies have shown that people with rheumatoid arthritis (RA) have a higher rate of heart disease than people that do not have RA. we believe this is caused by the inflammation produced by RA.

Full description

Aim 1: We want to study people with RA to see if we can detect very early changes in their heart muscle and compare these results to people who do not have RA.

Enrollment: 128 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Written informed consent
• Age >= 18
• RA only: meet American College of Rheumatology(ACR)criteria for Diagnosis of RA
• Controls only: no evidence of RA or other inflammatory disease

Exclusion criteria

• Previous or current heart failure or ischemic cardiovascular disease (eg stroke, myocardial infarction, angina, CABG, stent).
• Atrial fibrillation.
• Known structural or functional cardiac abnormality, including pulmonary htn.
• Glomerular filtration rate < 60 ml/min.
• Pregnancy or breastfeeding.
• Unable to perform MRI (claustrophobia, unable to fit in magnet,pacemaker,defibrillator or non-MR safe implant).
• Hypersensitivity to gadolinium.

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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128 participants in 2 patient groups

rheumatoid arthritis patients

Other group

Description:

People who have rheumatoid arthritis underwent cMRI

Treatment:

Other: cardiac Magnetic Resonance imaging

controls

Other group

Description:

people who do not have RA or other inflammatory disease underwent cMRI

Treatment:

Other: cardiac Magnetic Resonance imaging