Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy

Diskapi Yildirim Beyazit Training and Research Hospital

Status: Enrolling

Conditions: Postoperative Nausea and Vomiting (PONV); Pediatric Anesthesia; Inflammatory Biomarkers

Treatments: Other: Measurement of Preoperative Inflammatory Biomarkers

Study type: Observational

Funder types: Other

Identifiers

NCT07148063

AEŞH-EK-2025-205

Details and patient eligibility

About

Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).

Recent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators.

This prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.

Enrollment: 170 estimated patients

Sex: All

Ages: 1 to 8 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged between 1 and 8 years
• Patients with ASA physical status I-II
• Patients scheduled for elective orchiopexy
• Obtained written informed consent from parents/guardians

Exclusion criteria

• Patients younger than 1 year or older than 8 years
• Patients with ASA physical status III or higher
• Presence of acute infection signs
• History of previous nausea or vomiting