Inflammatory Biomarkers for the Diagnosis of oPRES

Dunjin Chen

Status: Completed

Conditions: Neutrophil-lymphocyte Ratio; Posterior Reversible Encephalopathy Syndrome; Inflammatory Biomarkers

Treatments: Other: Whether the PE or E patient combined with PRES

Study type: Observational

Funder types: Other

Identifiers

NCT05433870

2019B08

Details and patient eligibility

About

The purpose of this study is to explore the inflammatory biomarkers for the diagnosis of obstetric posterior reversible encephalopathy syndrome.

Full description

The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES to explore the inflammatory biomarkers for the diagnosis of oPRES during 2012 to 2021.Then, the investigators grouped all the patients into PRES group (PE or E with PRES) and NOT-PRES group (PE or E without PRES) according to the diagnostic criteria of PRES. Then, the investigators analysed the inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and so on of two groups, and compared the difference of tow groups.

Enrollment: 621 patients

Sex: Female

Ages: 16 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Pregnant women were diagnosed of PE or E.
2. All patients were examined the cranial imaging (MRI or CT), and imaging findings meeting the diagnostic criteria of PRES or normal.
3. all patients provided written informed consent.

Exclusion criteria

1. patients combined with other neurological disorders
2. patients combined with mental illness

Trial design

621 participants in 2 patient groups

PRES group

Description:

patients in PE or E with PRES

Treatment:

Other: Whether the PE or E patient combined with PRES

NON-PRES group

Description:

patients in PE or E without PRES