Inflammatory Biomarkers in Saliva at Depression

Medipol University

Status: Completed

Conditions: Inflammation; Inflammatory Response; Depression; Gingivitis

Treatments: Other: Periodontal clinical measurements, Saliva sampling

Study type: Observational

Funder types: Other

Identifiers

NCT06427902

Depression (Other Identifier)

Details and patient eligibility

About

The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis.

The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?

Full description

Background: The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease. The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 (TREM-1), peptidoglycan recognition protein 1 (PGLYRP1) and interleukin-1 beta (IL-1β) in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals.

Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits.

depression regardless of periodontal status.

Enrollment: 65 patients

Sex: All

Ages: 18 to 53 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients who were moderate in severity according to the test result, who had not started drug therapy yet and who had not received antidepressant medication in the last 12 months

Exclusion Criteria: Patients with

• psychotic disorders
• autism spectrum disorders
• other anxiety disorders
• bipolar disorder
• mental any organic mental disorder and
• smokers, substance users

Trial design

65 participants in 3 patient groups

depression with gingivitis (DG) group

Description:

The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders. the gingivitis group was determined by the criteria of pocket depth of 3 mm or less.

Treatment:

Other: Periodontal clinical measurements, Saliva sampling

depression with periodontally healthy (DPH) patients

Description:

The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders.

Treatment:

Other: Periodontal clinical measurements, Saliva sampling

systemically and periodontally healthy (SPH) individuals

Description:

This group contists of individuals who are systemically and periodontally healthy

Treatment:

Other: Periodontal clinical measurements, Saliva sampling