Inflammatory Biomarkers of Pediatric Pulmonary Hypertension

The Hospital for Sick Children

Status: Unknown

Conditions: Hypertension, Pulmonary

Treatments: Other: Blood test

Study type: Observational

Funder types: Other

Identifiers

NCT03581695

1000058900

Details and patient eligibility

About

To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared to those with CHD alone, or with healthy controls.

Enrollment: 60 estimated patients

Sex: All

Ages: 1 day to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

-patients of any age with congenital cardiac disease coming for catheterization of the right heart, or both the right and left heart.

Exclusion criteria

• active systemic infection
• current active cancer
• active cancer treatment
• prior bone marrow transplant
• prior solid organ transplant

Trial design

60 participants in 3 patient groups

Pulmonary Hypertension and Congenital Heart Disease

Description:

Pulmonary Hypertension and Congenital Heart Disease

Treatment:

Other: Blood test

Congenital Heart Disease

Description:

Congenital Heart Disease

Treatment:

Other: Blood test

Healthy Controls

Description:

Healthy Controls

Treatment:

Other: Blood test