Inflammatory Bowel Disease Cohort in Nantes (CELESTE)

Nantes University Hospital (NUH)

Status: Enrolling

Conditions: Inflammatory Bowel Diseases

Treatments: Other: Collection of biological samples

Study type: Observational

Funder types: Other

Identifiers

NCT06256393

RC23_0467

Details and patient eligibility

About

The CELESTE cohort will be a three-center prospective cohort associated with the creation of a biobank including Inflammatory Bowel Diseases (IBD) patients with active disease

Full description

The CELESTE cohort will be a prospective cohort of IBD patients followed up at Nantes University Hospital, Jules Verne Clinic (Nantes) and/or Confluent Private Hospital (Nantes). The multicentric nature of the cohort including a tertiary referral center and two secondary care centers is a major asset, enabling the enrolment of a broad spectrum of patients, from those naïve to any immunomodulatory treatment to those refractory to multiple biologic therapies.

It will be associated with a multi-omics biobank with the aim of identifying new cellular and molecular signatures of success of the therapeutic strategy at one year.

Enrollment: 360 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age;
• Patients with an established diagnosis of IBD: CD, UC, unclassified IBD or refractory chronic pouchitis;
• Patients with active disease requiring surgery or endoscopy, whether performed at diagnosis or prior to initiation of new therapy;
• Patients who have given written consent to participate in the study and to keep biological samples for research purposes

Exclusion criteria

• Patients refusing to participate in the cohort;
• Patients with chronic inflammatory bowel disease quiescent at inclusion;
• Patients with a contraindication to general anaesthesia;
• Vulnerable patients (under court protection, curators, guardians);

Trial design

360 participants in 1 patient group

Patients

Description:

Patients of both sexes, over 18 years of age, with an established diagnosis of IBD (Crohn's desease, ulcerative colitis, unclassified IBD or chronic pouchitis) will be eligible for inclusion in a consultation to schedule surgery or colonoscopy for disease relapse (at diagnosis or prior to initiation of treatment), irrespective of treatment received

Treatment:

Other: Collection of biological samples