Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation

Yonsei University

Status: Completed

Conditions: Patients With Postoperative Mechanical Ventilation After Liver Transplantation

Treatments: Other: Mechanical ventilatory lung care

Study type: Observational

Funder types: Other

Identifiers

NCT02402634

4-2014-0989

Details and patient eligibility

About

Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively. Some of the recipients experience difficulty in weaning off from the mechanical ventilator due to various causes. This study is to investigate the relationship between the inflammatory gene polymorphism, known for acute lung injury, and the duration of mechanical ventilatory care for such liver transplantation recipients.

Enrollment: 141 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. 20-65 years old
2. scheduled for liver transplantation

Exclusion criteria

1. Patients under mechanical ventilation prior to surgery
2. patients with muscular skeletal disorder, probable cause for respiratory depression
3. patients not able to read, or understand the consent form
4. ethnicity, other than asian
5. patients refusal

Trial design

141 participants in 1 patient group

Mechanical ventilatory lung care

Description:

liver transplantation recipients under mechanical ventilatory lung care

Treatment:

Other: Mechanical ventilatory lung care