Inflammatory Markers and Resistant Depression (InDep)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Depression

Treatments: Behavioral: psychometric scales; Procedure: blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT02847533

API/2014/50

Details and patient eligibility

About

This study focuses on blood inflammatory markers (pro-inflammatory cytokines, anti-inflammatory cytokines, monocytes costimulation molecules) in patients with resistant unipolar depression in comparison with non-resistant unipolar depressed patients.

Enrollment: 108 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• group 1: Patients with resistant MDD (at least 2 failed treatments for the current episode) ,current treatment with IRS or IRSNA,
• group 2: patients with MDD remission after response to an antidepressant treatment.

Exclusion criteria

• comorbid somatic or psychiatric disorders: chronic or acute inflammatory diseases, previous treatment with brain stimulation for the current episode, legal protection

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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108 participants in 2 patient groups

resistant depression

Other group

Description:

patients suffering from resistant unipolar depression (at least 2 failed antidepressant treatments for the current episode)

Treatment:

Procedure: blood sample

Behavioral: psychometric scales

non resistant depression

Other group

Description:

patients in remission from unipolar depressive disorder

Treatment:

Procedure: blood sample

Behavioral: psychometric scales