Inflammatory Markers: HOLEP Versus TURP

Adana City Training and Research Hospital

Status: Completed

Conditions: Prostate Hyperplasia

Treatments: Procedure: Surgery method

Study type: Interventional

Funder types: Other

Identifiers

NCT05108662

49-708

Details and patient eligibility

About

Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.

Full description

Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.

Enrollment: 50 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA scores I-III patients
• having benign prostatic hyperplasia
• undergoing HOLEP or TURP surgery under general anesthesia

Exclusion criteria

• immune system disease,
• diabetes mellitus,
• malignancy other than prostate disease,
• history of steroid use,

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

HOLEP

Active Comparator group

Description:

Patients with a prostate volume greater than 80 g

Treatment:

Procedure: Surgery method

TURP

Active Comparator group

Description:

Patients with a prostate volume less than 80 g

Treatment:

Procedure: Surgery method