Inflammatory Mediators Associated With Infection by Respiratory Syncytial Virus (IMAR)

Uppsala University

Status

Completed

Conditions

Respiratory Syncytial Virus Infections

Respiratory Tract Infections

Treatments

Other: RS-virus infection

Study type

Observational

Funder types

Other

Identifiers

NCT03757429

2017-515IMAR

Details and patient eligibility

About

Infection with human respiratory syncytial (RS) virus is the most common cause of hospital stay due to pediatric lower respiratory tract infection. An exaggerated immune response contributes to the pathogenesis and small children may have over reactive airways for a long time after an infection.

New research has shown that polymorphonuclear leukocytes (PMNs) are stimulated by the virus. Besides fighting the infection they also cause collateral damage to the host. Among other mechanisms PMNs stimulates mucus formation that affects breathing. They also secrete enzymes, toxic proteins and free radicals that may cause harm to lung tissue and airways.

The current project strives towards identifying and quantifying inflammatory mediators in sputum, urine and blood of children with severe RS-virus infection. The ultimate aim of the project is to, in detail, describe proteins contributing to the pathogenesis of the disease.

Enrollment

31 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Admission to pediatric intensive care unit
Clinical need for invasive ventilation
Clinical need for intravascular catheterization
Clinical need for urine bladder catheterization
Patients with verified or suspected RS-virus-infection or no respiratory tract infection (control group)

Exclusion criteria

• Chronic inflammatory lung disease